An experimental study involving statin-treated mice found that coenzyme Q10 could reverse atorvastatin-related mitochondrial dysfunction. atorvastatin-treated mice developed muscular mitochondrial dysfunction due to ubiquinone deficiency and a decrease in exercise endurance. The findings of this study in mice suggest that coenzyme Q10 supplementation may benefit those taking statin drugs by reversing some of the adverse effects induced by these medications. But coenzyme Q10 is not the only supplement that may be beneficial for those taking statins to control cholesterol. Vitamin D in a separate study was found to reverse the muscle pain and weakness associated with statin use, even when patients continued taking the statins.
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance," Muraki A, Miyashita K, et al, J Appl Physiol, 2012
Ahmed W, Khan N, Glueck CJ, Pandey S, Wang P, Goldenberg N, et al. Low serum 25(OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res 2009;153:11-16
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